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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. mate endurance contains 5-HTP, which acts on the same serotonin pathway as SSRIs and other serotonergic medications. If you take an antidepressant, a migraine medication, or any other drug affecting serotonin, talk to your prescriber before starting, and never stop a prescription on your own. Talk to your doctor before starting any supplement if you have a medical condition or take prescription medication.