Twelve Essential Ingredients for Treating Premature Ejaculation

The natural ingredients in mate endurance combine to provide clinically proven results in the effective treatment of premature ejaculation. In addition to the product’s efficacy, mate endurance comes with no lasting side effects. Alternative “solutions” to the management of premature ejaculation, such as benzocaine wipes, lidocaine spray or sertraline pills, come with a whole host of negative side effects, from penis numbing to erectile dysfunction. Mate’s approach is fresh and natural, so you can hold your head high and keep your body clean… whenever you get down and dirty.

As you’ll see below, mate endurance takes a holistic approach when it comes to premature ejaculation. PE is about more than just lasting longer. It’s about having a satisfying sexual experience. That’s why our solution addresses a whole host of components, from endurance, to achieving and maintaining an erection, to ensuring the sexual passion is there when sparks start to fly.

Ingredient 1: L-Tryptophan

L-Tryptophan is an amino acid which the body converts into 5-HTP, which is then converted to serotonin, melatonin, and Vitamin B6. For purposes of the treatment of premature ejaculation, serotonin is most important here. At a certain level of arousal, signals are sent from the brain to the penis. These signals are the basis of the ejaculatory process. A quick reaction on the part of the brain in sending these signals is what leads to premature ejaculation. In order to delay this signal, and thereby delay ejaculation, one may either inhibit excitatory or reinforce inhibitory pathways from the brain or from the periphery to the spinal cord. Whereas dopamine causes excitation of the ejaculatory neuroaxis, serotonin and nitric oxide cause inhibition.

L-Tryptophan is a naturally occurring ingredient which can be found in foods such as nuts and cheeses. Whereas sertraline similarly increases serotonin production, it does this at the cost of impacting erectile function and libido levels. As such, using a prescription medication such as sertraline for the treatment of premature ejaculation often does more harm than good.

Ingredient 2: L-Citrulline

L-Citrulline is another amino acid, but the body converts this one into L-Arginine. L-Arginine improves blood flow in the body by increasing nitric oxide production. In addition to inhibiting the excitatory pathways from the brain, and thereby delaying ejaculation, nitric oxide helps increase blood flow to where it’s needed most during sex, the penis! 

By relaxing blood vessels and increasing blood flow, L-Citrulline is able to support the flow of blood to the penis and help men achieve an erection despite increased serotonin production as a result of L-Tryptophan. That’s the real magic of mate endurance - an ability to address premature ejaculation without having to sacrifice one’s ability to achieve and maintain an erection.

Ingredient 3: Tribulus

Tribulus is a small leafy plant. Research has shown that tribulus can increase sexual desire in men, and in particular, increase sexual satisfaction in men with erectile dysfunction. In essence, tribulus is the 3rd component to mate endurance’s magic. The first is L-Tryptophan, which helps keep you slow & steady when things get hot & heavy. The second is L-Citrulline, to help achieve and maintain an erection. And lastly, tribulus, making sure you’re in the mood when the moment arises. 

Prescription medications for PE, such as sertraline, typically only address one of these three facets. As such, while endurance may improve, this will ultimately come at the detriment of erectile function and sexual drive. Mate endurance’s natural, rounded approach to the management of PE seeks to address each sub-component.

Ingredient 4: Grape Seed Extract

Grape seed extract has been shown to improve blood circulation by enhancing nitric oxide production. In other words, the ingredient complements L-Citrulline to harden your resolve... wink, wink.


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Ingredient 5: Cinnamon

Studies have shown cinnamon to improve hormonal balance and improve libido levels, thereby increasing sex drive. As mentioned by others who offer prescription products such as sertraline for the treatment of premature ejaculation, “at the full dose of 100mg per day, the most common side effects were dyspepsia (indigestion), feelings of anxiety, transient drowsiness and anorexia, as well as erectile dysfunction and reduced libido.” In other words, there is an expectation that one should be willing to improve performance at the expense of no longer being in the mood to perform. We think sex is to be enjoyed to the fullest, and that’s why we’ve selected only natural ingredients to ensure that’s the case.

Ingredient 6: Fenugreek

Fenugreek is a clover-like herb known to have numerous health benefits. In fact, researchers found that men taking fenugreek can boost their sex drive by at least a quarter, primarily by increrasing testosterone. Testosterone levels naturally decline as an individual grows older, and conditions such as obesity and diabetes are often linked with low testosterone levels. Fenugreek, like cinnamon and tribulus, is yet another natural, plant-based ingredient that helps ensure you’ve got the passion to put your newfound endurance to the test.

Ingredient 7 - 10: Niacin (Vitamin B3) / Pantothenic Acid (Vitamin B5) / Vitamin B6 / Vitamin B12

The above ingredients cover four of the eight different types of B vitamins. B vitamins have been found to support the production of sex and stress-management related hormones in the adrenal glands. In essence, they help mitigate stress levels while still ensuring that there are sufficient levels of libido and testosterone to spark sexual desire. In addition to supporting libido and testosterone levels, B vitamins can also play a role in erectile function. Niacin has been shown to improve erectile function, especially in men with higher levels of cholesterol. Like L-Citrulline and grape seed extract, niacin helps induce erectile function when things start to get hot and heavy. Niacin is naturally found in foods such as turkey, avocado, and peanuts. Studies have also shown a linkage between low Vitamin B12 levels and premature ejaculation. As such, this confluence of B vitamins combine to support endurance, erectile function and sexual hormones. 

Ingredient 11: L-Selenomethionine (Selenium)

L-Selenomethionine, or selenium, is an ingredient typically found in Brazilian nuts to boost an individual’s sex drive. It has been suggested that the ingredient can boost testosterone levels, thereby increase one’s sexual passions. 

Ingredient 12: Tyrosine

Tyrosine is an amino acid that is predominantly found in cheese. Similar to L-Tryptophan, the ingredient decreases stress and anxiety, so that one is not as impacted by the performance pressure that usually comes with sexual activities. The calmer one is, the better the likelihood they’ll find their sexual experience to be satisfying and rewarding. 

All in all, mate endurance provides you with the ingredients you need to enjoy a sexual encounter without any of the lasting side effects that come with other PE solutions, including numbing sprays and SSRIs. The above twelve ingredients essentially fall into three buckets:

  1. Helps directly address premature ejaculation by reducing anxiety levels and calming one down through increased serotonin production
  2. Helps improve erectile function, which is often negatively impacted when addressing premature ejaculation
  3. Helps increase libido and testosterone levels, thereby improving sex drive, which, like erectile function, is often hurt through the treatment of premature ejaculation and because of increased serotonin production 


This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment.